منابع مشابه
Myeloperoxidase: friend and foe.
Neutrophilic polymorphonuclear leukocytes (neutrophils) are highly specialized for their primary function, the phagocytosis and destruction of microorganisms. When coated with opsonins (generally complement and/or antibody), microorganisms bind to specific receptors on the surface of the phagocyte and invagination of the cell membrane occurs with the incorporation of the microorganism into an i...
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Our knowledge of the erythropoietin (Epo) molecule has come a long way since Carnot and Deflandre’s landmark observations, over a century ago, attributing the increase in red blood cells to a factor called ‘hemopoietin’. For decades, the scientific community thought that the role of Epo was limited to red blood cell production. However, since the mid 1990s, Epo has been shown to exert numerous ...
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The tumor suppressor protein p53, a crucial player in the DNA damage response, is regulated in many ways, most notably through ubiquitination. In this issue, Yuan et al. (2010) identify the deubiquitinating protease USP10 as a new regulator of p53 in the DNA damage response and tumor development.
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Activation of inflammatory reactions by the immune system is of vital importance to the preservation of cellular and organ integrity in a hostile environment. It is a complex and fine-tunedmechanism. Insufficient response may cause immunodeficiency resulting in infection and cancer while overactivity may result in diseases like arthritis, diabetes, atherosclerosis, ischemic heart disease, heart...
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Particularly in the field of advertising and in popular scientific journals, antioxidants such as β-carotene (from carrots) or lycopenes (from tomatoes) and the vitamins C and E are one-sidedly portrayed as substances capable of offering protection against cancer or ageing because they diminish or prevent the effects of free radicals. However, free radicals should by nomeans be considered as be...
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ژورنال
عنوان ژورنال: Journal of Leukocyte Biology
سال: 2005
ISSN: 0741-5400
DOI: 10.1189/jlb.1204697